Changes of resistance-associated variants in HCV NS5A region post vitamin D supplementation for patients with chronic hepatitis C

Changes of resistance-associated variants in HCV NS5A region post vitamin D supplementation for patients with chronic hepatitis C - Efficacy of vitamin D supplementation for resistance-associated variants in NS5A region

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018454

Enrollment

Registered

2015-07-29

Start date

2015-07-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic hepatitis C

Interventions

Patients were treated with vitamin D supplementation (2000IU/day, once daily, after breakfast)for 16 weeks.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Chronic hepatitis C patients with resistance-associated variants in HCV NS5A region.

Exclusion criteria

Exclusion criteria: 1. pregnant woman or lactating mother 2. poorly controlled heart failure 3. poorly controlled diabetes or hypertension 4. severe renal disorder 5. decompensated liver cirrhosis 6. other liver diseases, including autoimmune hepatitis, primary biliary cirrhosis and alcoholic hepatitis, liver failure 7. positive result for hepatitis B surface antigen and antibody to human immunodeficiency virus type-1 8. hypercarcemia 9. hyperparathyroidism 10. medication with other vitamin preparations 11. Judged by investigator not to be appropriate for inclusion in this study

Design outcomes

Primary

Measure	Time frame
The concentration of serum 25(OH)D3 after 16 weeks supplementation of vitamin D, and the prevalence of resistance-associated variants in NS5A region	—

Secondary

Measure	Time frame
The changes in laboratory tests associated with liver function and fibrosis after 16 weeks supplementation of vitamin D.	—

Countries

Japan

Contacts

Public ContactMasanori Atsukawa

Nippon Medical School Chiba Hokusoh Hospital Division of Gastroenterology

atsukawa-nms@umin.ac.jp0476-99-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026