Acute myocardial infarction
Conditions
Interventions
None listed
Sponsors
University of Yamanashi, Department of Internal Medicine II
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The study patients, who admitted to Yamanashi University Hospital, met all of the following inclusion criteria; 1. Patients with acute myocardial infarction (AMI), who received emergent coronary angiography and successful reperfusion therapy by primary percutaneous coronary intervention using stent within 24 hrs after onset of AMI. 2. The culprit lesion was the proximal portion of the left anterior descending coronary artery (LAD) 3. Patients tested for endothelial vasomotor function with acetylcholine infusion in the LAD 2 weeks and 6 months after AMI
Exclusion criteria
Exclusion criteria: The study patients met any of the following exclusion criteria were excluded: 1) organic stenosis > 30% in the LAD at 2 weeks and 6 months after AMI; 2) percutaneous coronary intervention at multiple segments of the LAD; 3) in-stent and peri-stent restenosis (> 30% diameter stenosis) at the 6 month study after AMI; 4) previous percutaneous coronary intervention in the LAD before AMI; 5) previous coronary artery bypass surgery before AMI; 6) cardiovascular events during 6 months after AMI; 7) congestive heart failure; 8) persistent atrial fibrillation or a paced rhythm; 9) presence of collaterals to the LAD with Rentrop grade > 2; 10) valvular heart diseases, secondary hypertension, stroke, renal dysfunction (serum creatinine concentration > 2.0 mg/dl) or other serious diseases, 11) Left main trunk disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following outcomes at 6 months and during 5.5 years after AMI will be evaluated. 1. Left ventricular function, 2. Targeted vessel revascularization in the culprit coronary artery, | — |
Countries
Japan
Contacts
Public ContactKiyotaka Kugiyama
Yamanashi University Hospital Internal Medicine II
Outcome results
None listed