Influence of ingestion of eicosapentaenoic acid-rich fish oil on muscle damage and delayed onset muscle soreness following eccentric contractions: a randomized, double-blind, placebo-controlled, parallel-group trial

Influence of ingestion of eicosapentaenoic acid-rich fish oil on muscle damage and delayed onset muscle soreness following eccentric contractions: a randomized, double-blind, placebo-controlled, parallel-group trial - Influence of eicosapentaenoic acid on muscle damage and delayed onset muscle soreness

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018285

Enrollment

Registered

2015-07-14

Start date

2015-07-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

muscle damage and delayed onset muscle soreness

Interventions

Tested material: EPA-rich fish oil Dosage: 2.4g/day Duration: 8 weeks Tested material: corn oil Dosage: 2.4g/day Duration: 8 weeks

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy male subjects

Exclusion criteria

Exclusion criteria: Subjects with /regular resistance training /no exercise /serious liver, kidney, heart, respiratory, endocrine or metabolic diseases/ scheduled for surgery during this study/ administration of regular medication / food allergies to fish/ participation of other clinical trial during this study/ restriction of exercise/ any reason in the opinion of the lead principal investigator not to take part in this study

Design outcomes

Primary

Measure	Time frame
1. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. During ECC, 1) electromyogram 2) isotonic contraction torque 2. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. Before and after ECC, 1) ultrasonic imaging analysis for elbow flexors 2) reactivity of electrical micro-stimulation 3) maximal isometric contraction torque 4) range of motion 5)muscle soreness measured as a visual analog scale 6)muscle soreness measured by algesiometer	—

Measure

Time frame

1. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. During ECC, 1) electromyogram 2) isotonic contraction torque 2. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. Before and after ECC, 1) ultrasonic imaging analysis for elbow flexors 2) reactivity of electrical micro-stimulation 3) maximal isometric contraction torque 4) range of motion 5)muscle soreness measured as a visual analog scale 6)muscle soreness measured by algesiometer

—

Secondary

Measure	Time frame
1. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. During ECC, analyzing ultrasonic imaging for elbow flexors. 2. After ingestion of tested materials for 8 weeks, subjects perform eccentric contraction (ECC) with elbow flexors. Before and after ECC, testing blood makers (creatine kinase, myoglobin, IL-6, TNF-alpha).	—

Countries

Japan

Contacts

Public ContactEisuke Ochi

Okayama University Graduate School of Education

eisukeochi@cc.okayama-u.ac.jp086-251-7750

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026