an exploratory study of the brief local brain hypothermia in combination with endovascular thrombectomy for patients with t-PA refractory cerebral ischemia in internal carotid artery territory

an exploratory study of the brief local brain hypothermia in combination with endovascular thrombectomy for patients with t-PA refractory cerebral ischemia in internal carotid artery territory - tPA COOL IVR study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018255

Enrollment

Registered

2015-07-10

Start date

2015-07-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral infarction

Interventions

Brief Local Brain hyporhermia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients who are able to be treated with endovascular embolectomy after intravenous tPA in 8 hours from the onset. 2) Patients who needs endovascular thrombetomy because of severe cerebral ischemia by occlusion of the main trunk in internal carotid artery system. 3) Patients with symptom (NIHSS>=5)after recanalization. 4)Written informed consent provided by the patient or his/her family member.

Exclusion criteria

Exclusion criteria: 1) Patients who cannot be submitted to angiography due to severe iodine allergy. 2) Patients with very light symptoms or quick improvement. 3) Patients with hemorrhagic lesions. 4) Patients with severe hepatic or renal disorder. 5) Patients with multiorgan failure or DIC due to cancer. 6) Patients with uncotrolled hypertention (systolic>185mmHg, diastoric >110mmHg). 7) Patients with uncotrolled glucose levels (<50 mg/dl, >400 mg/dl). 8) Patients with platelet count <100,000 /mm3. 9) Patients who are not suitable for the study in the opinion of the investigator.

Design outcomes

Primary

Measure	Time frame
The safety	—

Secondary

Measure	Time frame
1.The assessment of controlling the symptom after re-perfusion injury. 2.The assessment of infarction and cerebral edema due to images 3.the assessment of physical findings and clinical examination	—

Countries

Japan

Contacts

Public ContactToshiya Osanai

Hokkaido University Hospital Department of Neurosurgery

osanait@med.hokudai.ac.jp011-706-5987

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026