Comparative analysis of hypothermia and controlled normothermia on neurological outcome following return of spontaneous circulation after out-of-hospital cardiac arrest

Comparative analysis of hypothermia and controlled normothermia on neurological outcome following return of spontaneous circulation after out-of-hospital cardiac arrest - Comparative analysis of hypothermia and normothermia on neurological outcome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018229

Enrollment

300

Registered

2015-07-07

Start date

2015-07-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

return of spontaneous circulation after out-of-hospital cardiac arrest

Interventions

Controlled normothermia hypohtermia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Comatose patients (Glasgow Coma Scale <=8) whose spontaneous circulation was restored after out-of-hospital cardiac arrest

Exclusion criteria

Exclusion criteria: 1.Possible causes of coma originated from brain (drug overdose, head trauma, or cerebrovascular accident). 2.Core temperature below 30 degrees Celsius on admission 3.Patients with initial cardiac rhythm of asystole and with interval of more than 45 minutes from collapse to ROSC 4.Unstable circulation state after the return of spontaneous circulation and before randomization 5.Allergic to medicine which will be used in this study 6.Patients who are judged to be inappropriate for the study by the physician in charge

Design outcomes

Primary

Measure	Time frame
Cereberal Performance Category on 28th day after admission	—

Countries

Japan

Contacts

Public ContactHiromasa Yamamoto

Osaka City University, Graduate School of Medicine Department of Traumatology and Critical Care Medicine

hyamamoto@med.osaka-cu.ac.jp06-6645-3987

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026