Healing effect of a Vonoprazan or a Lansoprazole for artificial ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial.

Healing effect of a Vonoprazan or a Lansoprazole for artificial ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial. - Healing effect of P-CAB for artificial ulcer after ESD.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018188

Enrollment

200

Registered

2015-07-07

Start date

2015-07-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

early gastric cancer

Interventions

Eradication of H. pylori before ESD. Vonoprazan is given after ESD. Eradication of H. pylori before ESD. Lansoprazole is given after ESD. No eradication of H. pylori before ESD. Vonoprazan is given

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. A case included in the adaptation of the ESD treatment that followed "stomach cancer treatment guidelines" 2. A case of H.pylori-positive 3. A case of 20 years or older 4. A case that Performance status (ECOG) is 0, 1 or 2

Exclusion criteria

Exclusion criteria: 1. A case that takes steroid more than 15 mg 2. A case having serious complications (heart failure, renal failure, liver failure, respiratory failure) 3. A case to have an allergy career to a study drug 4. A case that it was not agree by the participation in this clinical study

Design outcomes

Primary

Measure	Time frame
The healing rate of artificial ulcer after endoscopic submucosal dissection is evaluated.	—

Countries

Japan

Contacts

Public ContactHiromitsu Ban

Shiga University of Medical Science Division of Digestive Endoscopy

hban@belle.shiga-med.ac.jp077-548-2217

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026