The effect of Yokukansan on medication overuse headache

The effect of Yokukansan on medication overuse headache - The effect of Yokukansan on medication overuse headache

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018148

Enrollment

Registered

2015-08-01

Start date

2015-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medication Overuse Headache

Interventions

TJ-54 Tsumura Yokukansan 7.5g/day 8weeks Placebo 7.5g/day 8weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: headache days >20days/month headache type: migraine serum potassium level before the start of treatment within 4 weeks should be in normal range

Exclusion criteria

Exclusion criteria: experience of taking yokukansan taking other Kampo-medicine having severe cardiac disease, liver disease, kidney disease, hematologic disorders, lung disease, or other severe disease related to life itself having psychological disorders such as depression or other disorders due to DSM-5 unable to take oral medicine under treatment of acupuncture, chiropractic, massage

Design outcomes

Primary

Measure	Time frame
Number of headache days Number of migraine attacks	—

Secondary

Measure	Time frame
Intensity of headache(VAS score) Intensity of anxiety(Hamilton AnxietyScale) Intensity of irritation HIT6 Questionnaire for Kanpo Medicine Number of tablets for acute medicine Laboratory test Side effect	—

Countries

Japan

Contacts

Public ContactMakiko Hirayama

Saitama Medical University Faculty of Medicine Department of Neurology

yokkan3@saitama-med.ac.jp049-276-1209

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026