Various circulatory diseases including aortic stenosis, mitral regurgitation, hypertrophic cardiomyopathy, pulmonary hypertension, acute pulmonary embolism, mechanical circulatory support, congenital heart diseases, and small-intestinal bleeding
Conditions
Interventions
None listed
Sponsors
The Research Group for the AVec Study (Main Offiece at IDAC,Tohoku University)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: This research is consisted following A and B lines. Research A: When patients undergo bleeding events and surgical therapy during follow-up period, they are evaluated for laboratory examination including VWF multimer analysis several times after the evemts. 1. Aortic stenosis with peak pressure gradients more than 30 mmHg evaluated with Doppler ultrasound cardiography (UCG), 500cases. 2. Mitral regargitation more than II degree at B-mode UCG, 500 cases. 3. Hypertrophic obstractive cardiomyopathy with intraventricular pressure gradient more than 20 mmHg, 200 caases. 4. Pulmonary hypertension (PH) more than 40 mmHg maximal trans-tricuspid valve pressure gradient estimated by Doppler UCG including primary pulmonary hypertension, collagen-disease-related PH, CTEPH, PH caused by congenital heart diseases, 500 cases. 5. Acute pulmonary embolism, 100 cases. 6. Patients with mechanical circulatory support 195 cases (percutaneous cardiopulmonary support 150 cases, extracorponeal left ventricular assist device (VAD) 15 cases, implantable left ventricular VAD) 7. Patients congenital heart diseases with possible high shear stress within bodies including grown-ups and those after surgical repair, 200 cases. Research B: patients with intestinal bleeding in following (a) and (b ) categories are enrolled, 200 cases: a: definite small-intestinal bleeding from angiodysplasia evaluated with capsule endoscopy or baloon-type small-intestinal endoscopy b: suspected small-intestinal bleeding compatible with following categories. (i) apparent gastrointestinal bleeding. No causative origin observed by upper and lower endoscopic examination. clinically considered small-intestinal bleeding. (ii) tumor lesion, inflammatory bowel diseases, infectious colitis, and drug-induced colitis are excluded by capsule endoscopy or baloon-type small-intestinal endoscopy
Exclusion criteria
Exclusion criteria: none
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study is a prospective observational study to evaluate and elucidate incidence and clinical condition such as values obtained by laboratory examinations of aVWS and related bleeding events in each target circulatory disease by transverse and longitudinal analyses. Further, patients with small intestinal bleeding will be also enrolled and the contribution of cardiovascular disease-related aVWS would be also evaluated in the same way. | — |
Secondary
| Measure | Time frame |
|---|---|
| Elucidation of relationship between aVWS or bleeding events and values of blood examination such as ADAMTS13 activity and multiuser analysis of VWF, in each circulatory disease. aVWS-related bleeding sites such as gastrointestinal tract in each circulatory disease. Elucidation of set-up that possibly inducing aVWS under treatment of mechanical circulatory support device | — |
Countries
Japan
Contacts
Public ContactHisanori Horiuchi
Tohoku University Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer
Outcome results
None listed