Venous thromboembolism after total knee arthroplasty and high tibial osteotomy with / without edxaban: a prospective study

Venous thromboembolism after total knee arthroplasty and high tibial osteotomy with / without edxaban: a prospective study - Venous thromboembolism after total knee arthroplasty and high tibial osteotomy with / without edxaban: a prospective study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018101

Enrollment

100

Registered

2015-06-26

Start date

2012-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis, rheumatoid arthritis, osteonecrosis

Interventions

To determine whether postoperative VTE is present and to evaluate the efficacy and safety of edoxaban for the prevention of patients undergoing TKA, OWHTO, or CWHTO, angiography of the pulmonary arter

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with osteoarthritis, osteonecrosis, and rheumatoid arthritis undergoing TKA, OWHTO, and CWHTO.

Exclusion criteria

Exclusion criteria: Patients with the presence of pre-operative VTE, severe renal impairment, and the use of anticoagulants, antiplatelet agents, thrombolytic agents, and other agents that impact on thrombus formation, are excluded.

Design outcomes

Primary

Measure	Time frame
Levels of coagulation and fibrinolysis markers are evaluated on the preoperative day and on postoperative days 1, 3, 7, and 14. To determine whether postoperative VTE is present and to evaluate the efficacy and safety of edoxaban for the prevention of patients undergoing TKA, OWHTO, or CWHTO, angiography of the pulmonary artery and deep veins of the lower limbs is performed in all patients on postoperative day 7.	—

Measure

Time frame

Levels of coagulation and fibrinolysis markers are evaluated on the preoperative day and on postoperative days 1, 3, 7, and 14. To determine whether postoperative VTE is present and to evaluate the efficacy and safety of edoxaban for the prevention of patients undergoing TKA, OWHTO, or CWHTO, angiography of the pulmonary artery and deep veins of the lower limbs is performed in all patients on postoperative day 7.

—

Countries

Japan

Contacts

Public ContactHideo Kobayashi

Yokohama City University School of Medicine Department of Orthopaedic Surgery

hi-deo@live.jp045-787-2800

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026