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Efficacy and safety of docosahexaenoic acid + eicosapentaenoic acid therapy in patients with successful coronary intervention (ESSENCE Study)

Efficacy and safety of docosahexaenoic acid + eicosapentaenoic acid therapy in patients with successful coronary intervention (ESSENCE Study) - ESSENCE Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000018056
Enrollment
40
Registered
2015-06-25
Start date
2015-07-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertriglyceridaemia

Interventions

The patients with hypertriglyceridaemia and successful coronary intervention are enrolled. The patients receive DHA+EPA (2g/day) and treat for 12 weeks. If the levels of triglyceride in blood is more

Sponsors

Department of Cardiology, Fukuoka University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Patients who had the levels of fasting triglyceride more than 150 mg/dl. 2.Age is 20 years old or more and gender is male or female. 3.Patinets with successful percutaneous coronary intervention 4.Patients who gave their written informed consent to participate for the present study.

Exclusion criteria

Exclusion criteria: 1.Severe cardiac failure 2.Severe liver dysfunction 3.Severe renal dysfunction 4.Pregnancy or lactation in women 5.Patients with a history of allergy to any component of the study medications 6.Ineligible patients according to the judgment by physician

Design outcomes

Primary

MeasureTime frame
Changes in triglyceride levels in blood.

Secondary

MeasureTime frame
Changes in pulse wave velocity. Changes in biochemical parameters (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol and fraction of fatty acid. Changes in triglyceride levels in blood(breakfact after 2, 4 and 8 hrs). Adverse effects. Investigate MACE (MI,TLR adnd Death) for 1 year.

Countries

Japan

Contacts

Public ContactShin-ichiro Miura

Fukuoka University Hospital Department of Cardiology

miuras@cis.fukuoka-u.ac.jp81-92-801-1011

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026