Preventive efficacy of post-operative fracture after a total knee replacement: comparative study of PTH and anti-RANKL treatment

Preventive efficacy of post-operative fracture after a total knee replacement: comparative study of PTH and anti-RANKL treatment - Preventive efficacy of post-operative fracture after a total knee replacement: comparative study of PTH and anti-RANKL treatment

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018048

Enrollment

100

Registered

2015-07-01

Start date

2015-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoporosis

Interventions

teriparatide denosumab

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients with osteoporosis undergoing total knee replacement provided a consent to participate in this study

Exclusion criteria

Exclusion criteria: patients undergoing treatment for osteoporosis

Design outcomes

Primary

Measure	Time frame
new fragility fracture bone mineral density by DEXA bone formation and resorption marker	—

Secondary

Measure	Time frame
change of bone mineral density around the implant after TKA	—

Countries

Japan

Contacts

Public ContactNoriaki Okumura

Shiga University of Medical Science Orthopaedic Surgery

noriaki@belle.shiga-med.ac.jp077-548-2252

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026