Parkinson disease
Conditions
Interventions
None listed
Sponsors
Utano National Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with PD who fulfilled the United Kingdom Parkinson's Disease Society Brain Bank clinical diagnostic criteria (steps 1 and 2), who were admitted to the Department of Neurology of National Regional Center for Neurological Disorders and National Hospital of Utano between January 2008 and December 2013. Subjects with both of the following conditions were included. (i) Plasma concentrations of high-sensitivity CRP for screening blood test were measured in the period when patients were not diagnosed as having any infections. (ii) Modified Hoehn and Yahr stage 4 or less at baseline.
Exclusion criteria
Exclusion criteria: Subjects with any of the following conditions were excluded. (i) Patients who developed dementia within 1 year of the onset of parkinsonism based on consideration of dementia with Lewy bodies (1-year rule).23 (ii) History of brain surgery. (iii) Having any infections within the one month prior to the enrollment. (iv) Concomitant chronic inflammatory diseases including autoimmune diseases or malignancy. (v) Taking corticosteroids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure was the change of the Unified PD Rating Scale Part III scores (on period) from the study enrollment to each of the five follow-up periods (the Day 1-90, 91-270, 271-450, 451-630, and 631-900). | — |
Countries
Japan
Contacts
Public ContactHideyuki Sawada
Utano National Hospital Clinical Research Center
Outcome results
None listed