Non randomized trial to compare efficacy of tolvaptan and trichlormethiazide in adult congenital heart disease

Non randomized trial to compare efficacy of tolvaptan and trichlormethiazide in adult congenital heart disease - Non randomized trial to compare efficacy of tolvaptan and trichlormethiazide

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000018009

Enrollment

Registered

2015-06-22

Start date

2014-04-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adult congenital heart disease

Interventions

administration of tolvaptan administration of trichlormethiazide

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.admitted to the hospital for congestive heart failure 2.water retention regardless of standard diuretic therapy 3.Sign of congestive heart failure 4. obtained written informed consent

Exclusion criteria

Exclusion criteria: 1.Ventricular assist device 2.Complicated with low cardiac output syndrome, HCM, under inotrope infusion, and hepatic coma. 3. Aneuria or uncontrolled diabetes.

Design outcomes

Primary

Measure	Time frame
Mortality in 6 month, rate and frequency of re-admission, urine osmolity and sodium concentration, serum electrolytes	—

Secondary

Measure	Time frame
body weight, sign of congestion, side effects	—

Countries

Japan

Contacts

Public ContactMikiko Shimizu

Tokyo Women's Medical University Pediatric Cardiology

okikim8111@hotmail.com03-3353-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026