knee osteoarthritis
Conditions
Interventions
Intervention/ 5-time weekly hyaluronan injection combined with monthly repetitive injections
Control / Only 5-time weekly hyaluronan injection
Sponsors
Tokyo Medical and Dental University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients who show Kellgren-Lawrence grade 1-3 knee osteoarthritis within 3 months 2. Pateints who did not receive hyaluronan injection therapy within recent 3 months 3. Patients who suffer from knee pain 4. Patients who give a written consent to the study
Exclusion criteria
Exclusion criteria: 1. Patients who have neurological and/or vascular complications which may affect the evaluation 2. Patients who have difficulty for evaluation because of their physical and/or mental condition 3. Patients who take not allowed medication for treatment of pain 4. Patients who have ill controlled DM, etc. 5. Patients who have possibility of taking other surgical treatments within a year 6. Patients who live distant from the hospital with difficulty of visiting frequently
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| patient-based subjective assessment | — |
Secondary
| Measure | Time frame |
|---|---|
| Radiographic assessment, MRI evaluation and physical evaluation | — |
Countries
Japan
Contacts
Public ContactKunikazu Tsuji
Tokyo Medial and Dental University Department of Cartilage Regeneration, Graduate School
Outcome results
None listed