The optimal degree of nitrous oxide inhalation edation -The effects of nitrous oxide inhalation on sympathetic nervous response to pain stimulation-

The optimal degree of nitrous oxide inhalation edation -The effects of nitrous oxide inhalation on sympathetic nervous response to pain stimulation- - Sleep/sedation and pressor response

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000017942

Enrollment

Registered

2015-06-18

Start date

2015-06-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

30% nitrous oxide inhalation 40% nitrous oxide inhalation

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy adult men

Exclusion criteria

Exclusion criteria: Overt history of chronic diseases (cardiopulmonary, neurological, renal diseases, renal artery stenosis, primary aldosteronism, and diabetes mellitus). Inflammatory dental diseases Sleep apnea Smokers BMI>32

Design outcomes

Primary

Measure	Time frame
Muscle sympathetic nerve activity	—

Secondary

Measure	Time frame
Blood pressure, Heart rate, Cardiac output, Stroke volume, Total peripheral resistance	—

Countries

Japan

Contacts

Public ContactYoshiyuki Okada

Matsumoto Dental University Special Care Dnetistry

okay@po.mdu.ac.jp0263-52-3100

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026