acute liver failure with hepatic coma and late onset hepatic failure
Conditions
Interventions
On-line continuous hemodiafiltration using HAYATE
Sponsors
Iwate Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients with acute liver failure with hepatic coma and late onset hepatic failure according to the diagnosiitc criteria in Japan. (2) A written informed consent from the patient or representative is necessary.
Exclusion criteria
Exclusion criteria: (1) Child or elderly person who is intolerable to extracorporeal circulation (2) Patient with overt brain edema (3) Patient with liver malignancy (4) Hyperacute-type liver failure (5) Patient whose conscious level can't be evaluated (6) Patient who is intolerable to extracorporeal circulation because of unstable hemodynamics (7) Inadequate condition as considered by primary physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Consciousness-recovery rate within 10 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in serum ammonia level Change in blood glutamine level Change in serum TNF-alpha, IL-6, and IL-1beta levels Period to consciousness recovery Bridge to liver transplantation | — |
Countries
Japan
Contacts
Public ContactKenji Sasaki
Iwate Medical University Liaison center office
Outcome results
None listed