acute bronchiolitis
Conditions
Interventions
To administer Heliox by a ventilator and/or a CPAP device. To continue to wean from ventilator and/or CPAP, or within 7 days whichever shorter.
Sponsors
Nagano Children's Hospital Division of anesthesiology
Tokyo Metropolitan Children'
s medical center Department of Pediatric Emergency &
Critical Care Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Less than 2 years old at the time of PICU admission. 2. On ventilator or CPAP. 3. the patients who are diagnosed to acute bronchiolitis Clinically (tachypnea, coughing, prolongation of expiratory time, expiratory stridor, moist rale and retraction), chest x-ray(with or without lung hyperinflation) and M-WCAS (more that 5). 4. Get informed consent from legal representative.
Exclusion criteria
Exclusion criteria: 1. Patients who have severe congenital heart diseases. 2. Patients who has severe chronic lung disease. 3. Patients who have severe malformation of bronchi or lung. 4. Patients who are diagnosed as bronchial asthma and under treatment. 5. Patients who have severe physiologic conditions continued more than 6 hours as follows. 1) OI>15cmH2O/mmHg 2) Mean arterial pressure<30mmHg 3) Heart rate>200bpm 6. Patients who have to use medical devices with hot wire flow sensor (exclude the device which is confirmed with Heliox). 7. Patients who are predicted that need Heliox inhalation more than 7 days. 8. Other patients who are identified as inappropriate for this study by the physicians in charge.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare Length of PICU stay in Heliox group with historical control group. The criteria of PICU discharge is; SpO2 is more than 92% and clinically stable more than 6 hours under CPAP less than 10cmH2O and FIO2 less than 0.4. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare Heliox group with historical control group. 1. Ventilation priod, CPAP priod, length of oxygen therapy, length of hospital stay, incidence rate of VAP, status of antibiotic usage. 2. To compare SpO2, EtCO2, PaO2, PaCO2, and tcPCO2 before Heliox administration with 15 minutes or 1 hour after Heliox administration . | — |
Countries
Japan,Asia(except Japan)
Contacts
Public ContactSeiki Abe
Nagano Children's Hospital anesthesiology
Outcome results
None listed