A prospective, randomized study to examine whether administration of plant extract improves outcomes of assisted reproductive technology (ART) therapy.

A prospective, randomized study to examine whether administration of plant extract improves outcomes of assisted reproductive technology (ART) therapy. - Examination of effectiveness of plant extract on assisted reproductive technology (ART) therapy.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000017758

Enrollment

100

Registered

2015-06-01

Start date

2015-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility of high age treated by assisted reproductive technology (ART) therapy.

Interventions

ART patients who meet inclusion criteria and do not meet exclusion criteria are prospectively allocated at random into two groups as follows

the control group who undergoes ART therapy without administration of plant extract, and the plant-extract group who undergoes ART therapy after one to two months of administration of plant extract. A

glucometabolism ex. (oral glucose tolerance test, C-peptide, Hb A1c, glycoalbumin, general chemistry, etc.), hormones (FSH, LH, E2, PRL, AMH, T, DHEA-S, etc.), measurements of blood advanced glycation

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: The study includes patients who satisfy all the following criteria; (1) 38-42 years of age, (2) to undergo the first, second or third attempt of assisted reproductive technology (ART) therapy, (3) no medication to affect the glucometabolism is nor has been administered.

Exclusion criteria

Exclusion criteria: Patients are excluded when they meet any of the following criteria; (1) definitely diagnosed diabetes mellitus, (2) organic uterine infertility (uterine anormaly, Asherman syndrome, etc.), (3) non-obstructive azoospermia.

Design outcomes

Primary

Measure	Time frame
The number of superior embryos.	—

Secondary

Measure	Time frame
Follicular growth, the numbers of retrieved oocytes, fertilized oocytes and embryos, pregnancy rates, and the changes in various metabolic and hormonal examinations.	—

Countries

Japan

Contacts

Public ContactMasao Jinno

Women's Clinic Jinno Reproductive Medicine

mjinno@s9.dion.ne.jp042-480-3105

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026