Healthy adults Prevention as follow, Obesity, dyslipidemia, hypertension, arteriosclerosis, diabetes mellitus, infarction or renal failure.
Conditions
Interventions
Placebo group (fake Kurozu containing diet) 20 ml of Fake Kurozu / day intervention period, 90 days
Trial group (Kurozu containing diet) 20 ml of Kurozu / day intervention period, 90 days
Sponsors
Kagoshima University
IMJ Kagoshima Faculty of Pharma Science, Teikyo University The Graduate School of Medicine, Faculty of Medicine, Osaka University Faculty of Nursing and Nutrition, Kagoshima Immaculate Heart University The University of Tokyo Hospital Department of Human Nutrition, Faculty of Human Nutrition, Seitoku University Department of Psychosomatic Medicine, Kagoshima University Graduate School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects who do not have allergy to rice or rice koji. Subjects who tend to be obesity. Subjects who were not patients of hypertension, dyslipidemia, or diabetes mellitus. Subjects who wish to improve eating habits and keep their health. Subjects who understand the purpose of this trial and want to join this trial. Subjects who was approved by the human ethics committee of Japan Society of Nutrition and Food Science and a written informed consent was obtained from each participant.
Exclusion criteria
Exclusion criteria: At the start of trial 1 Waist circumference, <85cm (men) or <90cm (women) 2 Blood pressure, over 140/90 mmHg, but a doctor concludes that the subject is not hypertension when the subject's blood pressure is under 147 mmHg. 3 Patient of hypertension 4 Patient of diabetes mellitus 5 Patient of dyslipidemia 6 Subjects lack cook skill or don't have any companions who have cook skill. 7 Subjects keep taking any supplements or medicines which affect glucose or lipid metabolism over 1 month 8 Subjects take any anti-obesity drugs or supplements. 9 Allergy to rice or rice koji. 10 Subjects keep taking over 10 ml of Kurozu or Kurozu supplements corresponding to 10 ml of Kurozu over 1 month. 11 Over 6.5% HbA1c (NGSP) 12 Over 126 mg/dl of fasting blood glucose 13 Over 150 mg/dl of triglyceride 14 Over 160 mg/dl of LDL-cholesterol If a doctor decides that the subject is needed medical treatment unless the value is <160 mg/dl, the subject is excluded. 15 Under 40 mg/dl of HDL-cholesterol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| After 90 days intake of Kurozu or fake Kurozu containing diet. Waist circumference Serum TG | — |
Secondary
| Measure | Time frame |
|---|---|
| After 90 days intake of Kurozu or fake Kurozu containing diet. LDL-cholesterol HDL-cholesterol Adiponectin (ratio of polymer and oligomer) Body weight, body fat weight, %body fat, lean body mass, muscle mass Basal metabolic rate, body mass index, total body water, quantity of bone mineral Blood pressure Cardio ankle vascular index Cva-a LF/HF-MEM Fasting blood glucose HbA1c (NGSP) Plasma anti oxidative power Plasma oxidation level, TBARS Plasma TNF-alpha Plasma CRP Plasma homocysteine Serum uric acid Plasma beta-Thromboglobulin Plasma plasminogen activator inhibitor-1 Plasma tissue-type plasminogen activator Plasma tissue factor pathway inhibitor Plasma tissue factor Plasma fibrinogen Serum creatinine and estimated glomerular filtration rate | — |
Countries
Japan
Contacts
Public ContactHiroaki Kanouchi
Kagoshima University Joint Faculty of Veterinary Medicine
Outcome results
None listed