apraxia of lid opening in Parkinson'
Conditions
Interventions
Arm 1 intervention consisted of 4%oxybuprocaine eye drop treatment, washout for 24 hours or more, and a saline eye drop treatment
Arm 2 intervention consisted of saline eye drop treatment, a washout p
Sponsors
Utano National Hospital, National Hospital Organization
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: PD patients with ALO. The ALO criteria were the following: 1) transitory inability to initiate lid opening; 2) no findings of ongoing orbicularis oculi contractions, such as lowering of the brows beneath the superior orbital margins; 3) vigorous frontalis contraction during the period of inability to raise eyelids; and 4) no ocular motor or ocular sympathetic nerve dysfunction or ocular myopathy.
Exclusion criteria
Exclusion criteria: 1) corneal disease such as keratitis, corneal erosion, or ulcers; 2) treatment with botulinum toxin A during the previous 4 months; 3) hypersensitivity to oxybuprocaine hydrochloride; and 4) baseline complete opening time (COT) < 1 second.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change of "complete opening time (COT) after 10-second eye closure" (at 13 minutes after eye drops from baseline) | — |
Secondary
| Measure | Time frame |
|---|---|
| The percentage change of COT from baseline | — |
Countries
Japan
Contacts
Public ContactMasayuki Kohsaka
Utano National Hospital, National Hospital Organization Clinical Research Center
Outcome results
None listed