Moyamoya disease
Conditions
Interventions
MRI, IMP-SPECT, resting state fMRI, MEG, neuropsychometric exam will be performed on the patient who undergoes surgery at the beginning of the study and 12 months later. MEG, resting state fMRI will
t undergo surgery at the beginning of the study and 12 months later. MEG, resting state fMRI will be performed 6 months after the beginning of the study.
Sponsors
Nagoya University graduate school of medicine Department of neurosurgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patient who are diagnosed as moyamoya disease rediographically and never performed surgical intervention. The age between 18 and 60, at the first time for participating the study (gender is not required). Laterality of disease is not required (including quasi moyamoya disease). The patient who are independent in daily life(modified RS<=2). No apparent intracranial infarction/hemorrhage scar expanding one cortical artery supplied area by radiographical examination(CT and/or MRI). No neurological symptom which may influence on performance of neuropsychometric testing (aphasia, hemianopsia, agnosia, etc) The patient who are able to understand the purpose of this study, and sign the documents after one's agreement on the informed consent (parent's signature is required in case of under 20 years old participants)
Exclusion criteria
Exclusion criteria: The patient who can't understand the purpose of this study. The patient who can't be performed MRI and/or MEG because of implanted metallic instrument/things inside one's body. The patient who are not diagnosed as moyamoya disease by multiple physicians in this research by imaging studies. The patient who are not adequate for participating in this study judged by the research physicians with some reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At the first phase of the study, MRI, resting state fMRI, IMP-SPECT, MEG, and neuropsychometric examination are performed in disease patients, and evaluated with comparison to the data-base of healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| After 6 months, resting state fMRI and MEG are performed again. After 12 months, MRI, resting state fMRI, IMP-SPECT, MEG, and neuropsychometric examination are performed again. These longitudinal data are compared between the patient groups with/without surgical intervention. | — |
Countries
Japan
Contacts
Public ContactYusuke Sakamoto
Nagoya University Graduate school of medicine Department of Neurosurgery
Outcome results
None listed