Elucidating neurophysiological mechanisms underlying effects of motor training and non-invasive brain stimulation on focal hand dystonia

Elucidating neurophysiological mechanisms underlying effects of motor training and non-invasive brain stimulation on focal hand dystonia - Effects of transcranial stimulation on pathophysiology of focal dystonia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000017590

Enrollment

Registered

2015-05-15

Start date

2015-05-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Focal dystonia

Interventions

trancranial direct current stimulation and motor retraining for 30 min trancranial direct current stimulation for 30 seconds (sham stimulation) and motor retraining for 30 min

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - A history of musical training for more than 15 years with professional education in musical conservatory - No metal implant due to surgery - No history of epilepsy - No prescription of medication for sleep-aid - No risk of claustrophobia - A person with an ability to understand explanation of the experimental contents and to make a decision concerning participation in the experiment - No history of taking GABA-related medications within 6 months prior to starting the experiment

Exclusion criteria

Exclusion criteria: - Bilateral dystonia - Cardiovascular diseases - Uncontrollable hypertension - Neither psychiatric nor neurological disorders except for focal hand dystonia - Acute disease affecting the whole body and high fever - Recent disease of the lungs - Serious disorder of liver and renal function - Serious orthopedic disorders - Serious cognitive and psychiatric disorders - Abnormal metabolic process - Implantation of metal devises such as pace makers, cochlear implant, and shunts - Pregnancy - A history of epileptic attacks - Intracranial pathology - A history of taking medications for lowering thresholds of cramping - Alcohol dependence - Serious cardiac disorder - Auditory functional abnormalities and tinnitus

Design outcomes

Primary

Measure	Time frame
- Motor-evoked potential elicited by a single-pulse transcranial magnetic stimulation (TMS) - Short intracortical inhibition and facilitation derived from double-pulse TMS - Structural and functional images of human brain using a magnetic resonance imaging (MRI) - Musical Instrument Digital Interface (MIDI) - Hand kinematics	—

Secondary

Measure	Time frame
- Personal traits evaluated by questionnaires - Resting state network derived from fMRI	—

Countries

Japan

Contacts

Public ContactShinichi Furuya

Sophia University Musical Skill and Injury Center

furuya@csl.sony.co.jp03-3238-8575

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026