Tapering and withdrawal of Methotrexate(MTX) or Tocilizumab(TCZ), after achievement of RA remission in concomitant use of MTX and TCZ,a randomized control study.

Tapering and withdrawal of Methotrexate(MTX) or Tocilizumab(TCZ), after achievement of RA remission in concomitant use of MTX and TCZ,a randomized control study. - Spacing tocilizumab vs tapering methotrexate study in Keio university, for rheumatoid arthritis patients In remission Phase.[SKIP] study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000017577

Enrollment

Registered

2015-05-31

Start date

2015-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rheumatoid arthritis

Interventions

continue treatment spacing and discontinue TCZ tapering and discontinue TCZ

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.RA patients who maintained remission(DAS28-ESR<2.6)for>=24weeks by administration of TCZ(8mg/kg)by interval of 4week and concomitant use of MTX(>=6mg/week)

Exclusion criteria

Exclusion criteria: 1.Patients who do not agree to participate in this study 2.Patient with any reasons for inadequate to participate in this study, judged by attending rheumatologist.

Design outcomes

Primary

Measure	Time frame
DAS28-ESR remission rate at 12week after discontinuing MTX or TCZ	—

Secondary

Measure	Time frame
1.discontinuation rate of TCZ 2.discontinuation rate of MTX 3.spacing interval of TCZ before RA flare 4.dose of MTX before RA flare 5.concentration of MTX-PG, extra/intra-cellular molecule at (1)initiation of tapering treatment (2)during tapering (3)after cessation of MTX or TCZ	—

Countries

Japan

Contacts

Public ContactShuntaro Saito

Keio University School of Medicine Division of Rheumatology, Department of Internal Medicine

shun081359@gmail.com03-3353-1211

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026