Frail elderly subjects
Conditions
Interventions
The first group receives leucine-, vitamin D-enrich supplement plus MCT (leucine + MCT) at dinner. The leucine-, vitamin D-enrich supplement (Amino L40) produced by Ajinomoto Inc. (Tokyo, Japan) is
Sponsors
Showa Women's University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Elderly subjects in a nursing care home for the elderly volunteered to participate in a 3-mo dietary supplement intervention program. All residents in this nursing care home need special care by other people for living. They are classified into Japanese nursing care levels with number between 1 and 5 based on assessed care needs.
Exclusion criteria
Exclusion criteria: Exclusion criteria are subjects with treated with parenteral nutrition, or difficulty of swallowing, or type 1 diabetes mellitus, severe heart failure, liver, kidney, blood disease, or FBS > 200 mg/dl, or blood creatinine >1.5 mg/dl or CRP >2.0 mg/dl or BMI > 23 to avoid a further increase in body weight, or food allergy to supplements used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle function (locomotive and respiratory) and cognitive function at baseline and after 3-mo intervention are compared. Mid-upper-arm muscle area (AMA) is estimated by measuring triceps skin fold thickness (TSF) and mid-upper-arm circumference (AC); strength in the upper extremities is measured by a handgrip dynamometry; strength in the lower extremities is estimated by the leg extension power; muscle function is estimated by gait speed and iteration numbers in legs open and close; strength of respiratory muscles is estimated by peak expiratory flow (PEF) ;cognitive function is estimated by Mini-Mental State Examination (MMSE) and NM scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Under fasting conditions, blood concentrations in total protein, albumin, creatinine, total cholesterol, HDL-cholesterol, LDL-cholesterol, Triacylglycerol, free fatty acid, choline esterase, blood sugar, HbA1c, white blood cell number, red blood cell number, hemoglobin concentration, hematocrit, platelet number, iron concentration, C-reactive protein, acetoacetic acid, 3-hydroxybutyric acid, and total ketone bodies at baseline and after 3-mo intervention are compared. | — |
Countries
Japan
Contacts
Public ContactOsamu Ezaki
Showa Women's University Department of Human Life Science and Culture, Graduate School of Human Life Sciences
Outcome results
None listed