Randomized clinical trial of preventive effect of acetazormide acetate for marked intraocular pressure (IOP) elevation after cataract surgery in eyes with pseudoexfoliation syndrome.

Randomized clinical trial of preventive effect of acetazormide acetate for marked intraocular pressure (IOP) elevation after cataract surgery in eyes with pseudoexfoliation syndrome. - Prevention of IOP elevation after cataract surgery in eyes with pseudoexfoliation syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000017556

Enrollment

Registered

2015-05-14

Start date

2015-03-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pseudoexfoliation syndrome

Interventions

1) Administering 2 tablets of acetadormide acetate for the first operated eye at 1 hour preoperatively, 30 eyes, 30 patients. 2) Administering 2 tablets of acetadormide acetate for the first operated

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with pseudoexfoliation syndrome of 40 years or older

Exclusion criteria

Exclusion criteria: 1) macular or corneal pathology 2) history of ocular surgery and inflammation 3) pupil diameter of less than 5.0mm when dilated 4) any difficulty in follow-up or examination

Design outcomes

Primary

Measure	Time frame
1. IOP measured using a rebound tonometer (I care) in a supine position. 1) Preoperatively 2) At the conclusion of surger:IOP is adjusted to a range between 15 and 25 mmHg. 3) 60 minutes postoperatively 4) 180 minutes postoperatively 5) 300 minutes postoperatively 6) 420 minutes postoperatively 7) 24 hours postoperatively	—

Secondary

Measure	Time frame
2. Postoperative inflammation Flare intensity at 5 hours postoperatively 3. Wound status Anterior segment-optical coherence tomography at 5 hours postoperatively 4. Others Visual acuity, refraction, corneal astigmatism	—

Countries

Japan

Contacts

Public ContactKen Hayashi

Hayashi Eye Hospital Department of Ophthalmology

hayashi-ken@hayashi.or.jp092-431-1680

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026