asthma
Conditions
Interventions
None listed
Sponsors
Nagoya City University Graduate School of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjective: Stable asthmatic patients presenting symptoms as related with untreated allergic rhinitis or chronic rhinosinusitis. Control group: 1. Asthmatic patients without symptoms as related with rhinitis. 2. Allergic rhinitis patients without asthma. 3. Chronic rhinosinusitis patients without asthma. 4. healthy volunteer
Exclusion criteria
Exclusion criteria: 1. Patients who are considered to have infectious disease like mycobacterium tuberculosis. 2. Current smoker, and ex-smoker with smoking history more than 5 pack-year. 3. Patients who can not perform laboratory tests correctly. 4. Patients who has oral steroids at the registration period. Except for the patients who had 2 weeks washout peroiod prior to registration. 5. Patients who was judged as inappropriate by investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asssociation between asthma severity and FeNO, nasal NO in asthmatic patients with rhinitis. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Correlation between nasal NO levels and otolaryngologic disease. 2. Relationship between response of FeNO/nasal NO levels and changes of asthma and rhinitis symptoms due to rhinitis treatment. 3. Correlation between nasal NO/FeNO levels and cellular components, liquid factor of nasal lavage, blood, and sputum. 4. The effect of nasal NO levels in allergic rhinitis and chronic rhinosinusitis on the presence or absence of asthma. 5. Associations of rhinitis or chronic rhinosinusitis to serum periostin levels | — |
Countries
Japan
Contacts
Public ContactTakamitsu Asano
Nagoya City University Graduate School of Medical Sciences Respiratory Medicine, Allergy and Rheumatology
Outcome results
None listed