Effect of COX-2 selective inhibitor to synovial fluids and synovial tissues of osteoarthritis of the knee at total knee replacement.

Effect of COX-2 selective inhibitor to synovial fluids and synovial tissues of osteoarthritis of the knee at total knee replacement. - Effect of COX-2 selective inhibitor to synovial fluids and synovial tissues of osteoarthritis of the knee.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000017481

Enrollment

Registered

2015-05-15

Start date

2009-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee

Interventions

celecoxib group diclofenac sodium group control group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Severe knee OA who were performed the total knee arthroplasty surgery.

Exclusion criteria

Exclusion criteria: Total knee arthroplasty for other reasons, patient with history of gastrointestinal bleedings or perforation.

Design outcomes

Primary

Measure	Time frame
To measure protein presence of cytokines and HA concentration in the synovial fluids.	—

Countries

Japan

Contacts

Public ContactDaisuke Takahashi

Hokkaido University Graduate School of Medicine Department of Orthopaedic Surgery,

rainbow-quest@pop02.odn.ne.jp011-706-5936

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026