Investigation of articular cartilage injury (joint space narrowing) using 3T Gd-DTPA enhanced MRI of wrist and finger joints in rheumatoid arthritis

Investigation of articular cartilage injury (joint space narrowing) using 3T Gd-DTPA enhanced MRI of wrist and finger joints in rheumatoid arthritis - Articular cartilage injury(joint space narrowing) using 3T Gd-enhanced MRI of wrist and finger joints in rheumatoid arthritis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000017464

Enrollment

100

Registered

2015-05-18

Start date

2015-05-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients 20 years old and over 2.Patients who can receive imaging examination, especially, Gd-DTPA MRI without contraindication 3.Patients who can well understand and obtain informed consent.

Exclusion criteria

Exclusion criteria: 1.Patients under 20 years old 2.Patients who have any contraindication with MRI(for example, pacemaker implantation, claustrophobia, allergy for Gd-DTPA, metal in body, etc.). 3.Patients who are considered inappropriate by physician (for example, lack the ability to understand, less or non-cooporative, etc.)

Design outcomes

Primary

Measure	Time frame
Change in MRI (joint space narrowing, synovitis, bone edema, bone erosion), plain radiographic findings (erosion, joint space narrowing, Genant-modified Sharp score) and HAQ (total score, each variables) during 1 year follow-up	—

Secondary

Measure	Time frame
Change in the following variables during the observational period: 1.Progression of cartilage injury (joint space narrowing) is parallel with the inflammation of the synovial tissues? 2.MRI joint space narrowing is correlated with MRI synovitis, bone edema, and bone erosion? 3.What biomarkers of serum and plasma are related to cartilage injury (joint space narrowing)? 4.MRI is better to evaluate the cartilage injury? 5.There are any differences with cartilage injury according to treatment regimen?	—

Measure

Time frame

Change in the following variables during the observational period: 1.Progression of cartilage injury (joint space narrowing) is parallel with the inflammation of the synovial tissues? 2.MRI joint space narrowing is correlated with MRI synovitis, bone edema, and bone erosion? 3.What biomarkers of serum and plasma are related to cartilage injury (joint space narrowing)? 4.MRI is better to evaluate the cartilage injury? 5.There are any differences with cartilage injury according to treatment regimen?

—

Countries

Japan

Contacts

Public ContactMami Tamai

Nagasaki University Hospital Department of Immunology and Rheumatology Nagasaki University Graduate School of Biomedical Sciences

tamaim@nagasaki-u.ac.jp095-819-7262

Outcome results