Pulmonary metastases from colorectal cancer
Conditions
Interventions
Peripheral blood samples will be drawn from CRC patients with PM prior to operation and will be tested for CTC enumeration.
Sponsors
Kawasaki Medical School, Department of General Thoracic Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with metachronous PM after complete resection of CRC (cancer of the colon, cancer of the rectum) in whom the metastatic lesions are judged to be completely resectable 2. Patients with no evidence of non-PM including resectable hepatic metastasis and with no history of treatment of metastasis 3. Patients with adequate major organ functions and with an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-2 who are judged capable of tolerating a major operation 4. Patients who personally have given informed consent in writing
Exclusion criteria
Exclusion criteria: 1. History of pulmonary resection or lung radiofrequency ablation (RFA) / radiation therapy at the time of enrollment 2. Serious drug allergy 3. Chest X-ray evidence of interstitial pneumonia or pulmonary fibrosis 4. Any or suspected intercurrent active infection 5. Pregnant women, nursing mothers, possibly pregnant women, and women with no intention of practicing contraception 6. Ongoing continuous treatment with systemic corticosteroid medication 7. Poorly controlled diabetes mellitus or any serious complication such as a cardiac disorder 8. History of active double cancer *Except for malignancies clinically judged to be non-invasive cancer such as carcinoma in situ *Except for malignancies which have not recurred in >5 years after radical treatment 9. Patients likely to be unable to personally give written informed consent and any other condition that the investigator feels would be inadequate for the safe conduct of this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CTC positivity rate for patients having undergone resection of PM from CRC | — |
Secondary
| Measure | Time frame |
|---|---|
| Relationship of the CTC positivity rate with postoperative recurrence and prognosis | — |
Countries
Japan
Contacts
Public ContactShinsuke Saisho
Kawasaki Medical School Department of General Thoracic Surgery
Outcome results
None listed