Type 2 diabetes
Conditions
Interventions
A) Rice before boiled mackerel, B) boiled mackerel before rice, C) grilled beef
A) boiled mackerel before rice, B) Rice before boiled mackerel, C) grilled beef
Sponsors
Kansai Electric Power Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Untreated individuals with type 2 diabetes who full fills following inclusion criteria and healthy volunteers 1) HbA1c 9.0% or less 2) BMI 35 or less 3) Indivisuals on diet and exercise therapies
Exclusion criteria
Exclusion criteria: Following individuals are excluded from the study 1)Indivisuals with any adjustments of any drugs during the study period 2)Individuals with moderate or severe renal impairment 3)Individuals on peritoneal dialysis or hemodialysis 4)Individuals with severe hepatic dysfunction 5)Individuals with shock, heart failure, myocardial infarct, pulmonary embolism, sever pulmonary dysfunction, hypoxemia 6)Individuals with excessive alcohol intake 7)Individuals with dehydration, and dehydration-causing severe GI symptoms including diarrhea and vomit 8)Individuals with severe ketosis, or coma. 9)Individuals with severe infection, in the perioperative period or with serious injury 10)Individuals with Hb <13.0 mg/dL (male) and Hb <12.5 mg/dL (female) 11)Individuals allergic to mackerels 12)Individuals with a history of GI operation 13) Individuals pregnant or possibly pregnant 14) Individuals found ineligible as a study patient according to the discretion of the investigator or sub-investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucose levels, their area under the curve, theri glucose levels, and their standard deviations before and after ingestion of steamed rice. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) levels of insulin, glucagon, GLP-1, GIP and their area under the curve before and after ingestion of steamed rice. 2) time required for 50% ofsteamed rice to exit the stomach (t1/2). | — |
Countries
Japan
Contacts
Public ContactDaisuke Yabe
Kansai Electric Power Hospital Center for Diabetes, Endocrinology and Metabolism
Outcome results
None listed