food allergy
Conditions
Interventions
Slow Low-dose Oral Immunotherapy Ingesting allergen(boiled egg white, whole milk, udon noodle) every day according to the protocol.
elimination diet
Sponsors
Aichi Children's Health and Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: patient with severe food allergy for egg, milk, wheat diagnosed by oral food challenge
Exclusion criteria
Exclusion criteria: patients during oral immunotherapy for other food antigen patients with severe comorbidity patients with uncontrollable asthma or atopic dermatitis patients whose parents can not manage adrenalin autoinjector patients who have developed anaphylaxis by tiny antigen (less than 1mL of milk or 1g of boiled egg, udon noodle) within one year before the oral food challenge. patients whom the doctor asses ineligible
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the proportion of patients with negative results of oral food challenge for boiled egg white, cow's milk, udon noodle (0.2 - 0.5 - 1 - 2 - 5g or mL 30min interval) | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety and continuity of the therapy. The threshold dose of antigen and severity of allergic reaction provoked in OFCs. The shift of laboratory data (e.g. specific IgE titer) The frequency of rescue drug use and emergency department visit due to expected and unexpected allergic reaction in both groups. | — |
Countries
Japan
Contacts
Public ContactShiro Sugiura
Aichi Children's Health and Medical Center Department of Allergy
Outcome results
None listed