anterior cruciate ligament injury
Conditions
Interventions
Two tapes (Zepolas Tape, Mikasa Seiyaku, Tokyo, Japan) are patched on the medial and lateral aspects of the knee, respectively, at 14h before sampling. Then, at 2h before sampling, the two tapes are r
Sponsors
Hokkaido University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) patients older than 20 years, (2) patients who are scheduled to undergo primary anterior cruciate ligament reconstruction, (3) patients who are voluntarily agreed to participate in research and have a signed informed consent document.
Exclusion criteria
Exclusion criteria: (1) patients who had received any flurbiprofen or ketoprofen preparation within 2 weeks before the start of the study, (2) patients who had received an injection of a steroid, sodium hyaluronate, etc, into the affected joint within 1 week before the start of the study, (3) patients with wounds or diseases in the skin around the knee, (4) patients with a history of hypersensitivity to a certain drug, (5) patients suffering from a peptic ulcer, (6) patients with severe underlying internal diseases (heart disease, renal disease, coronary artery disease, hematological disease, etc.) or history of such diseases, (7) patients with a history of hypersensitivity to a certain NSAID, (8) patients with a history of asthma due to hypersensitivity to aspirin, (9) pregnant or possibly pregnant women or nursing women and (10) other patients judged, for any reason, to be unsuitable for the study by the attending physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tissue concentrations of flurbiprofen after topical application and oral administration of flurbiprofen | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory evaluation of blood and urine samples before and after flurbiprofen administration | — |
Countries
Japan
Contacts
Public ContactKazunori Yasuda
Hokkaido University Hospital Department of Sports Medicine
Outcome results
None listed