Unresectable colorectalcancer with hepatic metastases
Conditions
Interventions
None listed
Sponsors
Gastroenterological Surgery1, Hokkaido University Graduate school of medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The cases histologically diagnosed as colorectal cancer 2. The cases with evaluative resectable hepatic metastatic lesions ,synchronously or metachronously 3. Unresectable hepatic metastases mean anatomic difficulty and so on. 4. The cases with possibility of hepatic resection after panitumumab chemotherapy 5. The age is 20 years old or older. 6. Performance status is 0-2 cases 7. A major organ function is maintained by a laboratory study within 14 days before registration. 8. An agreement is obtained in a document from the patients after informed consent.
Exclusion criteria
Exclusion criteria: 1. The cases with serious drug hyper reaction against panitumumab, fluorouracil folinic acid, oxaliplatin, irinotecan 2. The cases with serious hypersensitivity having functional disorder or sensory disturbance 3. The cases with bone marrow suppression or its history, systemic infection, interstitial pneumonia, diarrhea, ileus, a lot of ascites or hydrothorax, icterus 4. The cases with interstitial pneumonia or its history 5. The cases with serious complications - Poor control diabetes mellitus - Heart failure beyond NYHA3 - Renal failure - Liver failure 6. The cases with mutative or unjudged type about KRAS status 7. The cases without a history of chemotherapy 8. Pregnant or lactating women 9. The cases judged to be unsuitable for registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete hepatic resection rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Hepatic resection rate, response rate, complications after hepatic resection, adverse event | — |
Countries
Japan
Contacts
Public ContactNorihiko Takahashi
Hokkaido University Hospital Gastroenterology1
Outcome results
None listed