Exploratory research on the combination therapy of the endovascular thrombectomy and the local brain hypothermia in severe cerebral ischemia within internal carotid artery territory

Exploratory research on the combination therapy of the endovascular thrombectomy and the local brain hypothermia in severe cerebral ischemia within internal carotid artery territory - COOL IVR study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000017304

Enrollment

Registered

2015-05-01

Start date

2013-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral infarction

Interventions

Local Brain hypothermia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) tPA contra-indicated patients who can be treated with endovascular thrombetomy within 8 hours from the onset. 2) Patients who needs endovascular thrombetomy because of severe cerebral ischemia by occlusion of the main trunk in internal carotid artery system. 3 )Written informed consent provided by the patient or his/her family member.

Exclusion criteria

Exclusion criteria: 1) Patients who cannot be submitted to angiography due to severe iodine allergy. 2) Patients with very light symptoms or quick improvement. 3) Patients with hemorrhagic lesions. 4) Patients with severe hepatic or renal disorder. 5) Patients with multiorgan failure or DIC due to cancer. 6) Patients with uncotrolled hypertention (systolic>185mmHg, diastoric >110mmHg). 7) Patients with uncotrolled glucose levels (<50 mg/dl, >400 mg/dl). 8) Patients with platelet count <100,000 /mm3. 9) Patients with severely compressed ventricle due to brain edema. 10) Patients who are not suitable for the study in the opinion of the investigator.

Design outcomes

Primary

Measure	Time frame
The safety	—

Secondary

Measure	Time frame
1,The achievement degree of temperature lowering 2,The change of symptom 3,The infarction and edema formation in radiological findings 4,The physical findings and laboratory data	—

Countries

Japan

Contacts

Public ContactTakeo Abumiya

Hokkaido University Hospital Department of Neurosurgery

abumiya@med.hokudai.ac.jp011-706-5987

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026