osteoporosis and sarcopenia
Conditions
Interventions
Drug therapy (bisphosphonate, vitamin D3) with exercise.
Drug therapy (bisphosphonate, vitamin D3) without exercise.
Sponsors
Department of Orthopaedic Surgery Graduate School of Medicine Chiba University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Osteoporosis patients. In DXA, bone density YAM is less than 80% in either of the lumbar spine or femur. 2) Patients that meet the definition of sarcopenia, who have muscle mass reduction, and either of decline of both sides grip strength (male; 25kg or less, female; 20kg or less) or walking speed (following 0.8 m / s). Walking ability is determined by the following interview, Can you cross the crosswalk during the green light? 3) Patients who agreed to participate in this study. 4) Patients who hope for drug prescription or exercise therapy on an outpatient basis. 5) Patients who have never taken bisphosphonates so far.
Exclusion criteria
Exclusion criteria: 1) Patients who have done exercise therapy already. 2) Patients with thyroid dysfunction, pituitary dysfunction,or the parathyroid dysfunction. 3) Patients with acute spinal compression fracture (within 3 months after injury).Chronic fracture is not excluded. 4) Patients who have been determined to be unsuitable for this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transition of low back pain by Numerical Rating Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Bone density, muscle mass, muscle strength, changes in the body's ability 2)Changes in intramuscular fat degeneration 3)Changes in bone metabolism markers 4)Trends of low back pain (JOABPEQ) | — |
Countries
Japan
Contacts
Public ContactKazuki Fujimoto
Graduate School of Medicine Chiba University Department of Orthopaedic Surgery
Outcome results
None listed