steroid resistant drug-induced lung injury
Conditions
Interventions
polymyxin B-immobilized fiber column I do for 2 days. A principle is performed for more than 6 hours per once.
Sponsors
Graduate School of Medicine, Osaka City University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)PaO2 is less than 80 Torr by the patient diagnosed as steroid treatment-resistant drug-induced lung injury.. mild PaO2 >= 80 Torr. moderate 60 Torr<= PaO2<= 80 Torr severe PaO2 < 60 Torr( PaO2/FiO2 < 300). 2) Patients who received PMX-DPH evaluated with P/F ratio.( P/F ratio is less than 300 or less than 60 mmHg of PaO2 under room air inspiration)
Exclusion criteria
Exclusion criteria: 1) pregnant woman, lactating woman or patient with a possibility of the pregnancy 2) The patients who has the past of allergy to blood purification and extracorporeal circulation method of treatment 3) Other non-approval medical equipment or the patient who participates in a clinical trial of medicine approving ly. 4) The patients for whom the value of this clinical study is difficult for a terminal cancer's, chronic renal insufficiency's and death's within 7 days being predicted 5) The patients who could admit clear pulmonary infection, pneumothorax, pulmonary embolism and heart failure by a clinical judgement 6) The patients who has an experience of PMX-DPH before agreement acquisition 7) The patients who judged that an implementation responsibility doctor or an allotment doctor was unsuitable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| P / F ratio at 48 hours after PMX treatment. | — |
Countries
Japan
Contacts
Public ContactHiroshi Kamoi
Graduate School of Medicine, Osaka City University department of respiratory medcine
Outcome results
None listed