A new management method for propofol intravenous sedation using a target-controlled infusion (TCI) pump -The investigation of the optimal initial target blood concentration value in resetting strategy for the target blood concentration at optimal sedation level-

A new management method for propofol intravenous sedation using a target-controlled infusion (TCI) pump -The investigation of the optimal initial target blood concentration value in resetting strategy for the target blood concentration at optimal sedation level- - The investigation of the optimal initial target blood concentration of propofol in resetting strategy for the target blood concentration at optimal sedation level using TCI pump

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000017197

Enrollment

Registered

2015-04-20

Start date

2010-04-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mainly impacted teeth

Interventions

TCI is started after the initial target blood concentration of propofol have been set at 2.2mcg/ml. TCI is started after the initial target blood concentration of propofol have been set at 2.6mcg/ml

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Forty-five patients who were scheduled to undergo oral surgery (mainly extraction of impacted tooth) under local anesthesia with intravenous sedation of propofol using the present method

Exclusion criteria

Exclusion criteria: habitual user of tranquilizer patient with liver or renal dysfunction obesity patient who's body mass index was more than 30%

Design outcomes

Primary

Measure	Time frame
1)Maximum difference between the brain concentration at optimal sedation during induction and the target blood concentration at each point during surgery 2)The duration till optimal sedation was achieved	—

Secondary

Measure	Time frame
1)SPO2, blood pressure 2)Brain concentration at optimal sedation during induction	—

Countries

Japan

Contacts

Public ContactToshiaki Fujisawa

Hokkaido University Hospital Department of Dental Anesthesiology

fujitosi@den.hokudai.ac.jp011-706-4345

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026