The assessment of endothelial function: significance in the diagnosis and management of dyslipidemia (an observational study).

The assessment of endothelial function: significance in the diagnosis and management of dyslipidemia (an observational study). - endothelial function in dyslipidemia

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000017145

Enrollment

180

Registered

2015-04-16

Start date

2014-08-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyslipidemia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) familial hypercholesterolemia 2) hyperlipoproteinemia (Fredrickson types 4 and 5) 3) other types of primary dyslipidemia 4) diabetic dyslipidemia

Exclusion criteria

Exclusion criteria: 1) patients with peripheral artery diseases of upper limbs 2) patients who are considered inappropriate as subjects for FMD and NMD tests

Design outcomes

Primary

Measure	Time frame
1) endothelium-dependent vasodilatation (FMD) 2) endothelium-independent vasodilatation (NMD)	—

Secondary

Measure	Time frame
1) surrogate marker of atherosclerosis (intima-media thickness (IMT), pulse wave velocity (PWV), cardio-ankle vascular index (CAVI), ankle brachial index (ABI)). 2) lipid profiles (total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, remnant-like particle-cholesterol (RLP-C), Lp(a), fatty acids, apoA1, apoB, apoC2, apoC3, apoE). 3) safety of nitroglycerine in NMD test.	—

Countries

Japan

Contacts

Public ContactHiroaki Okazaki

Graduate School of Medicine, The University of Tokyo Department of Diabetes and Metabolic Diseases

hokazaki-tky@umin.ac.jp+81-(0)3-3815-5411

Outcome results