Advanced or recurrent uterine corpus cancer
Conditions
Interventions
Paclitaxel 80mg/m2 day1, 8, 15+ Carboplatin AUC 6 day1 every 3 weeks
Sponsors
Kansai Clinical Oncology Group
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1),2),7);Women 20-75 years of age with histologically confirmed uterine corpus cancer, as endometrioid carcinoma, serous carcinoma, mucinous carcinoma, clear cell carcinoma, squamous cell carcinoma, traditional cell carcinoma, carcinosarcoma, or undifferentiated carcinoma. A) Patients with FIGO stage III had residual tumor. B) FIGO stage IV. C) Recurrence after first-line radical treatment. D) Recurrence after second line chemotherapy or radiotherapy. 3), 6) No prior therapy, over 6 months after chemotherapy with platinum plus taxane (only one regimen was permitted), or over 3 months chemotherapy after non-platinum and non-taxane chemotherapy. 4)Measurable lesion 5)No bilateral hydronephrosis 8)Performance status (ECOG);0-2 9)laboratory date in two weeks a) neutrophil; more than 1500/mm3 b) platelet; morethan 100000/mm3 c) hemoglobin; more than 10g/dl d) total bilirubin; more than 1.5mg/dl e) serum creatinine; less than1.5mg/dl f) Ccr calculated by Cockcroft's formula; more than 50ml/min 10) life expectancy of more than 3 months 11) written informed consent
Exclusion criteria
Exclusion criteria: 1)motor or sensory neuropathy with dysfunction 2) alcoholic hypersensitivity 3)bacterial infection to needtreatment 4) myocardial infarction within 6 months 5) unstable angina 6) poor control diabetes 7) active multiple malignancy 8) Interstitial pneumonia, pulmonary fibrosis 9) Paclitaxel or CBDCA is contra-indicated. 10) HBs-Ag(+) 11) Paralytic or mechanical bowel obstruction 12) History of severe drug-induced hypersensitivity syndrome 13) Any other cases who are regarded as inadequate for study enrollment by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| response rate | — |
Countries
Japan
Contacts
Public ContactKensuke Hori
Kansai Rosai Hospital obgy
Outcome results
None listed