Association of ghrelin and leptin in cardiovascular autonomic dysfunction in patients with primary dysautonomia.

Association of ghrelin and leptin in cardiovascular autonomic dysfunction in patients with primary dysautonomia. - Association of ghrelin and leptin in cardiovascular autonomic dysfunction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000017036

Enrollment

Registered

2015-04-03

Start date

2015-04-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

autonomic failure such as Parkinson&#39

Interventions

blood test of Leptin and Ghrelin blood test of Leptin and Ghrelin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: neurodegenerating disease with autonomic dysfunction

Exclusion criteria

Exclusion criteria: Individuals with diabetes mellitus, any known heart disease, hypertension, Cussing syndrome, rheumatism, difficulty in blood drawing, or other neurological disorders were excluded.

Design outcomes

Primary

Measure	Time frame
We evaluate the relation with these hormones and cardiac parameters such as orthstatic hypotention, postprandial hypotension, CVR-R, and cardiac MIBG. The first two years, we collect the date of about 50 patients and 25 normal controls. If there exist any relation with the secretion and cardiovascular dysautonomia, we will follow the patients and observe whether the progression of the disease have some relation with these hormons.	—

Measure

Time frame

We evaluate the relation with these hormones and cardiac parameters such as orthstatic hypotention, postprandial hypotension, CVR-R, and cardiac MIBG. The first two years, we collect the date of about 50 patients and 25 normal controls. If there exist any relation with the secretion and cardiovascular dysautonomia, we will follow the patients and observe whether the progression of the disease have some relation with these hormons.

—

Secondary

Measure	Time frame
We also evaluate the relation with drug, smell function, MMSE, and UPDRS.	—

Countries

Japan

Contacts

Public ContactIto Mizuki

Nagoya University Graduate School of Medicine neurology

itohm@med.nagoya-u.ac.jp+81-52-744-2385

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026