Analysis of Dendritic cells in blood and focal area in patients with refractory inflammatory diseases

Analysis of Dendritic cells in blood and focal area in patients with refractory inflammatory diseases - Dendritic cell analysis in refractory inflammatory diseases

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000017035

Enrollment

Registered

2015-04-03

Start date

2015-04-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Refractory inflammatory disease (interstitial pneumonia, bronchial asthma, Crohn&#39

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients suffering from interstitial pneumonia, bronchial asthma, inflammatory bowel disease was admitted to hospital (Crohn's disease, ulcerative colitis, Behcet's disease) in Kansai Medical University Hirakata hospital.

Exclusion criteria

Exclusion criteria: 1.minors and adults with no judgment ability 2.patients whom physician has determined that inappropriate

Design outcomes

Primary

Measure	Time frame
1. ELISA method for serum and HMGB1, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, IL-15, IL-18, IL -21, IL-22, IFN-alpha,IFN-gamma,TNF 2. mononuclear cell fraction, dendritic cells, immune cell markers by flow cytometry (CD11c, CD14, BDCA1, BDCA2, BDCA3, BDCA4, OX40L, ICOSL, GITRL, and analyzed by staining 4-1BBL, RANKL, TLR) 3. sections during tissue biopsy and surgical resection; staining and analysis using an antibody XCR1 and TLR family antibodies.	—

Measure

Time frame

1. ELISA method for serum and HMGB1, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, IL-15, IL-18, IL -21, IL-22, IFN-alpha,IFN-gamma,TNF 2. mononuclear cell fraction, dendritic cells, immune cell markers by flow cytometry (CD11c, CD14, BDCA1, BDCA2, BDCA3, BDCA4, OX40L, ICOSL, GITRL, and analyzed by staining 4-1BBL, RANKL, TLR) 3. sections during tissue biopsy and surgical resection; staining and analysis using an antibody XCR1 and TLR family antibodies.

—

Countries

Japan

Contacts

Public ContactTomoki Ito

Kansai Medical University First Dept. Internal Medicine

itot@hirakata.kmu.ac.jp81-72-804-2425

Outcome results