Takotsubo cardiomyopathy
Conditions
Interventions
We will assess the stress reaction after we perform the standard autonomic function test of participants. All the medications which might affect the autonomic nervous system were withheld for at lea
self introduction, a funny story of recent or a touching tale. They will speech in front of the medical profession(s) for 3 minutes.
Sponsors
Tokyo Women's Medical University
Tokai University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: A. Definition criteria of TCM 1. Transient hypokinesis, akinesis, or dyskinesis of the left ventricular midsegments with or without apical involvement; the regional wall motion abnormalities extend beyond a single epicardial vascular distribution; a stressful trigger is often, but not always present. 2. Absence of obstructive coronary disease or angiographic evidence of acute plaque rupture. 3. New electrocardiographic abnormal- ities (either ST-segment elevation and/or T-wave inversion) or modest elevation of cardiac troponin. 4. Absence of:recent significant head trauma, intracranial bleeding, pheochromocytoma, myocarditis, hypertrophic cardiomyopathy. B. Subjects inclusion criteria 1. Age >= 20 years old. 2. TCM patietns: History of TCM more than the prior 3 weeks with well-preserved general condition. 3. Healthy subjects: Matched by a comparable age and sex of TCM patients.
Exclusion criteria
Exclusion criteria: 1. Patients who have uncontrolled cardiovascular diseases such as congestive heart failure, ischemic heart disease, hypertension, arrhythmia 2. Patients who have uncontrolled diabetes meltis 3. Pregnant or lactating women 4. Patients who have overt concomitant disease 5. Patients who are not eligible for this study by study doctors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is plasma norepinephrine and epinephrine during the stress test between TCM and healthy subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondly outcome is blood pressure, heart rate, indexes of autonomic function test and genetic polymorphisms of adrenoceptors between TCM and control subjects. | — |
Countries
Japan
Contacts
Public ContactKyoko Sato
Tokyo Women's Medical University, East Medical Center Department of Medicine
Outcome results
None listed