Infertility patients with aging undergoing in vitro fertilization-embryo transfer
Conditions
Interventions
Duration of ingestion: 6 months Propolis or placebo: 2 tablets after every meal, 3 times a day Combined therapy: one FSH/hMG injection (150-300 IU) per day until maturation of follicles, one hCG inj
Sponsors
St. Marianna University School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Infertile female patients undergoing IVF-ET treatment 2) >=38 years of age and < 48 years of age when we receive written informed consent from the patients 3) Out patients in our hospital 4) Patients with written informed consent after explanation of this clinical study
Exclusion criteria
Exclusion criteria: 1) Patients with ingestion of other dietary supplements within one menstrual cycle prior to the initiation of study 2) Patients who decided to be unsuitable for this study by physicians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Using Veeck criteria for the classification of embryos with their morphology that reflect the oocyte quality, we score the quality of day 2 or 3 embryo obtained under IVF cycles during 6 months of the dietary supplement treatment and compare their values with those in placebo controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| We compare the proportions of fertilization (fertilized oocytes/retrieved oocytes, pregnancy (pregnant cycles/embryo transfer cycles), abortion (abortion cycles/pregnant cycles) between dietary supplement treatment and placebo groups. We also compare the concentration of makers for oxdative stress and immune-related factors (inflammatory cytokines and auto-antibodies). | — |
Countries
Japan
Contacts
Public ContactKazuhiro Kawamura
St. Marianna University School of Medicine Obstetrics and Gynecology
Outcome results
None listed