Fast Antidepressant Efficacy and Central Mechanisms of Single Low-Dose Ketamine Injection in Treating Major Depression: a double-blind and randomized-controlled trial and image study

Conditions

Treatment-resistant depression, TRD

Pei‐Chi Tu, Wan-Chen Chang, Tung‐Ping Su, Shu‐Chen Wei, Cheng‐Ta Li et al. (8 authors)

Molecular Psychiatry2024-07-066 citations

Cytokine- and Vascular Endothelial Growth Factor-Related Gene-Based Genome-Wide Association Study of Low-Dose Ketamine Infusion in Patients with Treatment-Resistant Depression.

Tsai SJ, Kao CF, Su TP, Li CT, Lin WC, Hong CJ, Bai YM, Tu PC, Chen MH.

2023-02-1010 citations

10.1007/s40263-023-00989-7

Using classification and regression tree modelling to investigate treatment response to a single low-dose ketamine infusion: Post hoc pooled analyses of randomized placebo-controlled and open-label trials.

Chen MH, Wu HJ, Li CT, Lin WC, Bai YM, Tsai SJ, Hong CJ, Tu PC, Cheng CM, Su TP.

2020-11-1117 citations

10.1016/j.jad.2020.11.045

Happiness During Low-Dose Ketamine Infusion Predicts Treatment Response

Mu‐Hong Chen, Shu‐Chen Wei, Hui-Ju Wu, Ya‐Mei Bai, Cheng‐Ta Li et al. (10 authors)

The Journal of Clinical Psychiatry2020-11-0911 citations

10.4088/jcp.20m13232

Interventions

Ketamine 0.5mg/kg Ketamine 0.2mg/kg PBO

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: diagnosis of major depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (DSM-IV-TR)

Exclusion criteria

Exclusion criteria: 1) Use of CNS intoxicant within the previous 24 hours or urine toxicology screen positive for drugs of abuse 2) Overdose, within previous 24 hours, of any agent which would compromise ketamine metabolism 3) Symptoms of substance abuse/dependence(except nicotine dependence) within 6 months 4) Lifetime use of ketamine or phencyclidine(PCP) 5) Diagnosis of psychosis or bipolar disorder

Design outcomes

Primary

Measure	Time frame
PET MRI MADRS	—

Countries

Asia(except Japan)

Contacts

Public ContactCheng-Ta Li

Taipei Veterans General Hospital Psychiatry

on5083@msn.com+81-1886228757027

Outcome results

None listed