Eosinophilic chronic rhinosinusitis
Conditions
Interventions
160 patients with chronic rhinosinusitis take actual drug for 8 weeks.
160 patients with chronic rhinosinusitis take placebo for 8 weeks.
Sponsors
University of Fukui
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patients who had a diagnosis of eosinophilic chronic rhinosinusitis using JESREC (Japanese epidemiological survey of refractory eosinophilic chronic rhinosinusitis) diagnostic criteria.
Exclusion criteria
Exclusion criteria: 1)The patient who is complicated with a nose disease (severe septum deviation, severe allergic rhinitis, nose or paranasal sinus tumor) that make this study difficult. 2)The case that the steroid dosage cannot cancel for the treatment of this disease and other diseases. 3)The case that has allergy for Natto or soybean. 4)Under during the pregnancy or the nursing 5)Patient during medical treatment of immunity 6)The patient who judged that the medical attendant was inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation improvement effect of the nasal polypus 8 weeks after the nattokinase dosage | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation symptom score, QOL, and CT score 8 weeks after the nattokinase dosage | — |
Countries
Japan
Contacts
Public ContactShigeharu Fujieda
University of Fukui Otorhinolaryngology Head & N
Outcome results
None listed