Patients with resectable thoracic esophageal cancer who are planned to undergo esophagectomy with gastric tube reconstruction and 2 or 3 field lymphadenectomy
Conditions
Interventions
After patients are randomly allocated to RY and Non-RY groups, RY group undergo gastric tube reconstruction with duodenal diversion plus Roux-en anastomosis.
After patients are randomly allocated to R
Sponsors
Osaka Medical Center for Cancer and Cardiovascular Diseases
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. histologically proven esophageal cancer by endoscopic biopsy 2. resectable cases, cT1b-3,Nany,M0 by preoperative staging, 3. preserve normal swallowing function and can eat and drink 4. 80 years old or younger 5. PS 0-2 6. Vital organ functions within 7days before entry are preserved. 7. Written informed consentis ontained from each patient.
Exclusion criteria
Exclusion criteria: 1. synchronous other malignant cancer within 1 year 2. Miocardial infarction, Master two steppositive on ECG 3. preoperative respiratory test, FEV1.0 is less than 50% 4. prior chemotherapy or radiationtherapy within 6 months 5. prior gastric or intestinal resection 6. severe absorptive disturbance 7. severe postoperative complications (anastomotic leakage, ileus, intraabdominal abcess, pneumonia, etc) 8. pregnant 9. other severe co-morbidities 10. In case where surgeon judge that entry to the study is impossible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative QOL at 1year assessed by DAUGS-32 questionare | — |
Countries
Japan
Contacts
Public ContactKazuyuki Itoh
Osaka Medical Center for Cancer and Cardiovascular Diseases Research Institute
Outcome results
None listed