Effects of bisoprolol transdermal patch for perioperative myocardial injury in patients undergoing non-cardiac surgery (Multi center Randomized Control Trial)

Effects of bisoprolol transdermal patch for perioperative myocardial injury in patients undergoing non-cardiac surgery (Multi center Randomized Control Trial) - MAMACARI study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000016908

Enrollment

240

Registered

2015-03-25

Start date

2015-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with hypertension undergoing non-cardiac surgery (RCRI&gt

Interventions

The patient undergoing operation was given bisoprolol transdermal patch(4mg) before 1 week operation. control

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (a) Hyptertension (b) operation with general anesthesia (c) RCRI 2 or more (d) age over 60 year old

Exclusion criteria

Exclusion criteria: (a) treated with beta blocker before randamization (b)contraindication for beta blocker(c) absolute indication for beta blocker including severe myocardial ischemia and severe tachycardia (d) planning for PCI or CABG in study period (e) End stage renal disease eGFR<15 or dialysis

Design outcomes

Primary

Measure	Time frame
rise in high sensitive Troponin T on one day after operation	—

Countries

Japan

Contacts

Public ContactHironobu Toda

Okayama University Graduate School of Medicine Department of Cardiovascular Medicine

hiromail1979@yahoo.co.jp086-235-7351

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026