Preliminary study of the effect of tokishakuyakusan on ocular blood flow in the patients with normal tension glaucoma

Preliminary study of the effect of tokishakuyakusan on ocular blood flow in the patients with normal tension glaucoma - The effect of tokishakuyakusan on ocular blood flow in the patients with normal tension glaucoma

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000016865

Enrollment

Registered

2015-03-21

Start date

2015-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

normal tension glaucoma

Interventions

Traditional Japanese Kampo medicine tokishakuyakusan (TJ-23), 7.5g/day, orally, for 6 months

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. systolic blood pressure < 130 mmHg and systolic blood pressure < 85 mmHg 2. intra ocular pressure <= 21 mmHg 3. with no significant abnormality in an examination for slit lamp microscopy and angle 4. with glaucoma-related optic disc shape in funduscopy 5. with glaucoma-related field change by at least two times of reliable visual field tests 6. written informed consent can be obtained from the participant

Exclusion criteria

Exclusion criteria: 1. When there is hypotension, circulatory disease, endocrine disease, a cause including excessive anemia are identified, and the cause is judged if treatment is necessary. 2. pregnant 3. history of allergy to Kampo medicine 4. history of unpleasantness, gastrointestinal disorder by the Kampo medicine

Design outcomes

Primary

Measure	Time frame
ocular blood flow	—

Countries

Japan

Contacts

Public ContactShin Takayama

Tohoku University Graduate School of Medicine Comprehensive Education Center for Community Medicine

takayama@med.tohoku.ac.jp022-717-8010

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026