Comparison examination of microbiota in mouth, intestine and vagina before and after medication of a raw bacillus agent (an active bacterial probiotics, Bio-Three) to the threatened premature delivery patient who requires in-hospital treatment, and examination about validity of preterm delivery medical treatment

Comparison examination of microbiota in mouth, intestine and vagina before and after medication of a raw bacillus agent (an active bacterial probiotics, Bio-Three) to the threatened premature delivery patient who requires in-hospital treatment, and examination about validity of preterm delivery medical treatment - Comparison examination of microbiota in mouth, intestine and vagina before and after medication of a raw bacillus agent to threatened preterm delivery, and examination about validity of preterm delivery medical treatment

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000016860

Enrollment

Registered

2015-03-21

Start date

2014-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

threatened preterm delivery

Interventions

A raw bacillus agent (Bio-Three 6 tablets per day, 14 days) is prescribed.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: a patient of threatened preterm delivery (tocolysis index, 2 to 6) who needs in-hospital treatment, who was transferred from other hospitals or was out-patient in our hospital at 22 to 34 weeks of gestation

Exclusion criteria

Exclusion criteria: 1) multiple pregnancy 2) previous medication of antibiotics within 14 days 3) premature rupture of the membranes 4) tocolysis index of 7 or higher (there is a possibility of becoming a preterm delivery within one week) 5) allergy to Bio-Three 6) ulcerative colitis and Crohn's disease

Design outcomes

Primary

Measure	Time frame
a change of microbiota in mouth, intestine and vagina	—

Countries

Japan

Contacts

Public ContactArihiro Shiozaki

University of Toyama Obstetrics and Gynecology

s33shio@med.u-toyama.ac.jp076-434-7357

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026