Extensive-Stage Small-Cell Lung Cancer
Conditions
Interventions
None listed
Sponsors
Dept. of Respiratory Medicine, Kurashiki Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Written voluntary informed consent 2.Patients aged >= 20 years 3.Pathologically-confirmed small-cell lung cancer 4.Extensive-stage disease 5.Standard platinum-containing chemotherapy is scheduled as first-line chemotherapy 6.Performance Status of 0 or 1 (Eastern Cooperative Oncology Group) 7.Adequate organ function
Exclusion criteria
Exclusion criteria: 1.Concomitant other malignancy 2.Life expectancy <= 3 months 3.Use of steroid hormone, immunosuppressant, or biologic drug within 4 weeks at the time of enrollment 4.Severe active infection or poorly controlled disease ( e.g. hypertension, diabetes mellitus, cardiac disorder, gastro-intestinal bleeding, and so on) 5.Pregnant, possibly pregnant or lactating woman 6.Requiring radiation therapy to brain, mediastinum, or lung 7.Concomitant obvious interstitial lung disease on chest computed tomography 8.Poorly controlled malignant effusion requiring drainage 9.Otherwise determined by the investigator or the attending physician to be unsuitable as a subject in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The association between serum anti-RPL29 antibody levels and overall survival | — |
Secondary
| Measure | Time frame |
|---|---|
| 1, The association between serum anti-RPL29 antibody levels and progression-free survival in first-line chemotherapy 2, The association of serum anti-CTLA-4 antibody levels with overall survival or progression-free survival in first-line chemotherapy 3, The association of serum anti-PD-1 antibody levels with overall survival or progression-free survival in first-line chemotherapy 4, The association of serum anti-BTLA antibody levels with overall survival or progression-free survival in first-line chemotherapy | — |
Countries
Japan
Contacts
Public ContactSatoshi Ikeo
Kyoto University Hospital Dept. of Respiratory Medicine
Outcome results
None listed